MYELOID NEOPLASIA Stromal SPARC contributes to the detrimental fibrotic changes associated with myeloproliferation whereas its deficiency favors myeloid cell expansion
نویسندگان
چکیده
1Tumor Immunology Unit, Human Pathology Section, Department of Health Sciences, University of Palermo, Palermo, Italy; 2Molecular Immunology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; 3Department of Hematology and Oncological Sciences L.e.A. Seràgnoli, University of Bologna School of Medicine, Bologna, Italy; 4Section of Biochemical Sciences, Department of Experimental Medicine and Neuroscience, University of Palermo, Palermo, Italy; 5Hematology Unit, Department of Oncology and Hematology, University of Palermo, Palermo, Italy; 6Laboratory of Experimental Oncology, CRS Development of Biomolecular Therapies, Istituto di Ricovero e Cura a Carattere Scientifico Rizzoli Institute, Bologna, Italy; 7Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy; and 8Hematopathology Division, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY
منابع مشابه
Stromal SPARC contributes to the detrimental fibrotic changes associated with myeloproliferation whereas its deficiency favors myeloid cell expansion.
In myeloid malignancies, the neoplastic clone outgrows normal hematopoietic cells toward BM failure. This event is also sustained by detrimental stromal changes, such as BM fibrosis and osteosclerosis, whose occurrence is harbinger of a dismal prognosis. We show that the matricellular protein SPARC contributes to the BM stromal response to myeloproliferation. The degree of SPARC expression in B...
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